The 10th Proteasome & Autophagy Congress will cover up-to-date knowledge on proteolytic systems (Ubiquitin Proteasome System and Autophagy) and their implication in different diseases.

The Scientific and Organizing Committees set up an attractive scientific program with outstanding international speakers that have contributed to the characterization of the UPS and Autophagy, and to the development of new major concepts in proteolysis. The congress provides an opportunity for scientists to improve the transfer of knowledge from basic to applied science and from group leaders to young investigators, and to open new space of interest and investigation for the near future.

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-       The 1^st session of the Congress will cover new insights on Proteasome structure and function. 

-       The 2^nd session will be dedicated to signaling pathways that control the fine-tuning of protein modifications by ubiquitin (ubiquitination and deubiquitination) and Ub-like proteins. 

-       The 3^rd session will cover Autophagy-linked proteolysis. Autophagy is interconnected with the UPS and plays also a major role in cell homeostasis (particularly for eliminating abnormal organelles, controlling energy balance, and protein trafficking). 

The meeting is held in Clermont-Ferrand, the capital of Auvergne, with its University, University Hospitals, and affiliated research Institutes such as the INRAE, the French National Research Institute for Agriculture, Food, and Environment.

Auvergne is a magnificent province of France, famous for its volcanoes such as the Puy de Dôme, its history, castles, Romanesque churches, and gastronomy. The 'Chaîne des Puys - Limagne fault tectonic arena' is an exceptional geological site inscribed on the UNESCO world heritage list.

We are very grateful to our invited speakers for accepting to participate in this meeting.

We hope that the congress will contribute promoting interactions and collaborations among participants, which is an important objective of this meeting.